REDUCTION OF LEFT-VENTRICULAR SPONTANEOUS ECHO CONTRAST IN CARDIOMYOPATHY BY ACUTE INOTROPIC INTERVENTION OR AGGRESSIVE THERAPY

The purpose of this study was to determine whether improvement of left ventricular (LV) systolic function could reduce the severity or elimi nate LV spontaneous echo contrast found with transthoracic echocardiog raphy in a group of patients with advanced cardiomyopathy. A successfu l reduction of this by hemodynamic means might indicate an additional beneficial method of helping prevent thromboembolism in advanced cardi omyopathy. Six patients with advanced cardiomyopathy and demonstrating spontaneous echo contrast on transthoracic echocardiography were trea ted with acute inotropic drug infusions or aggressive medical therapy to improve LV systolic function to determine whether reduction in spon taneous contrast could be achieved by such means. A spontaneous echo c ontrast scoring system was devised: 0 to 4, indicating absent to sever e. Six observers, unacquainted with the study plan, were blinded as to the source of the 12 pre-and post-therapy two-dimensional echocardiog rams obtained and re-recorded in a random sequence, and were asked to grade the degree of spontaneous echo contrast. In all six patients, LV spontaneous echo contrast was reduced by improvement in LV systolic f unction (average score lowered from 2.94 to 1.25, p < 0.005). Among pa tients with cardiomyopathy at high risk for LV thromboembolism, as ind icated by the presence of LV spontaneous echo contrast, improvement in LV systolic function may serve as an adjunct to anticoagulation or, i n some cases, as a substitute when the latter is contraindicated in th e prevention of thromboembolism. The results obtained suggest merit in prospective, long-term studies of a larger group of such patients.