Dental caries (decay), the most prevalent of diseases, represents a he
alth problem of immense proportions(1). It principally affects posteri
or (back) teeth on occlusal (biting) and approximal (adjacent contacti
ng) surfaces. Caries starts as a subsurface demineralization of enamel
, may progress to the underlying dentine and, eventually, to cavitatio
n of the surface. Accurate diagnosis before cavitation would permit ta
rgeted preventive treatment, thereby significantly improving dental he
alth and reducing the need for expensive drilling and filling. Inacces
sibility of caries initiation sites and recent changes in lesion morph
ology contribute to the relatively poor accuracy of conventional diagn
ostic methods(2). Among alternative techniques, measurements of electr
ical resistance(3-5) have shown the most promise. Here we described ne
w experimental technique that demonstrates an outstanding 100% correla
tion between a.c. impedance measurements of whole teeth and the actual
extent of approximal caries in vitro. Only relatively minor modificat
ions should be required to transfer the technique to in vivo applicati
ons.