Jm. Lopez et al., STEROL REGULATION OF ACETYL-COENZYME-A CARBOXYLASE - A MECHANISM FOR COORDINATE CONTROL OF CELLULAR LIPID, Proceedings of the National Academy of Sciences of the United Statesof America, 93(3), 1996, pp. 1049-1053
Transcription from the housekeeping promoter for the acetyl coenzyme A
carboxylase (ACC) gene, which encodes the rate-controlling enzyme of
fatty acid biosynthesis, is shown to be regulated by cellular sterol l
evels through novel binding sites for the sterol-sensitive sterol regu
latory element binding protein (SREBP)-1 transcription factor, The pos
ition of the SREBP sites relative to those for the ubiquitous auxiliar
y transcription factor Sp1 is reminiscent of that previously described
for the sterol-regulated low density lipoprotein receptor promoter, T
he experiments provide molecular evidence that the metabolism of fatty
acids and cholesterol, two different classes of essential cellular li
pids, are coordinately regulated by cellular lipid levels.