REDUCED CARNITINE PALMITOYL TRANSFERASE-ACTIVITY AND ALTERED ACYL-TRAFFICKING IN RED-BLOOD-CELLS FROM HEMODIALYSIS-PATIENTS

Authors
DELOSREYES B PEREZGARCIA R LIRAS A ARENAS J
Citation
B. Delosreyes et al., REDUCED CARNITINE PALMITOYL TRANSFERASE-ACTIVITY AND ALTERED ACYL-TRAFFICKING IN RED-BLOOD-CELLS FROM HEMODIALYSIS-PATIENTS, Biochimica et biophysica acta. Molecular basis of disease, 1315(1), 1996, pp. 37-39
Citations number
14
Categorie Soggetti
Biology,Biophysics
Journal title
Biochimica et biophysica acta. Molecular basis of disease → ACNP
ISSN journal
09254439
Volume
1315
Issue
1
Year of publication
1996
Pages
37 - 39
Database
ISI
SICI code
0925-4439(1996)1315:1<37:RCPTAA>2.0.ZU;2-P
Abstract
We measured carnitine palmitoyl transferase activity, free carnitine, and long chain acyl carnitine levels in erythrocytes from 15 uremic pa tients and 25 controls. Carnitine palmitoyl transferase levels in pati ents were significantly lower than in controls. The levels of free car nitine and long chain acyl carnitines as well as the long chain acyl c arnitine/free carnitine ratio were significantly higher in patients th an in controls. Our results suggest that hemodialysis causes alteratio n in the acyl-trafficking in red blood cells membrane.