AGING IS ASSOCIATED IN FEMALES WITH A DECLINE IN THE CONTENT AND ACTIVITY OF THE B-C(1) COMPLEX IN SKELETAL-MUSCLE MITOCHONDRIA

Authors
BOFFOLI D SCACCO SC VERGARI R PERSIO MT SOLARINO G LAFORGIA R PAPA S
Citation
D. Boffoli et al., AGING IS ASSOCIATED IN FEMALES WITH A DECLINE IN THE CONTENT AND ACTIVITY OF THE B-C(1) COMPLEX IN SKELETAL-MUSCLE MITOCHONDRIA, Biochimica et biophysica acta. Molecular basis of disease, 1315(1), 1996, pp. 66-72
Citations number
24
Categorie Soggetti
Biology,Biophysics
Journal title
Biochimica et biophysica acta. Molecular basis of disease → ACNP
ISSN journal
09254439
Volume
1315
Issue
1
Year of publication
1996
Pages
66 - 72
Database
ISI
SICI code
0925-4439(1996)1315:1<66:AIAIFW>2.0.ZU;2-U
Abstract
The activity of cytochrome-c oxidase [E.C. 1.9.3.1] and b-c(1) complex [E.C. 1.10.2.2.] and the content of cytochromes 6, c + c(1) and a + a (3) in human skeletal muscle mitochondria from orthopaedic patients (1 08 women and 68 males), of age ranging between 10 and 90 years, have b een analyzed. The activity of cytochrome c-oxidase declines with age b oth in females and males, The activity of b-c(1) complex, which in you ng females is significantly higher than in young malts, declines sharp ly in females, but not in males, with ageing. These results reveal tha t the content of active b-c(1) complex in muscle mitochondria is speci fically controlled by female sex hormones.