OLIGONUCLEOTIDES WITH ALTERNATING ANIONIC AND CATIONIC PHOSPHORAMIDATE LINKAGES - SYNTHESIS AND HYBRIDIZATION OF STEREO-UNIFORM ISOMERS

Authors
HORN T CHATURVEDI S BALASUBRAMANIAM TN LETSINGER RL
Citation
T. Horn et al., OLIGONUCLEOTIDES WITH ALTERNATING ANIONIC AND CATIONIC PHOSPHORAMIDATE LINKAGES - SYNTHESIS AND HYBRIDIZATION OF STEREO-UNIFORM ISOMERS, Tetrahedron letters, 37(6), 1996, pp. 743-746
Citations number
9
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
37
Issue
6
Year of publication
1996
Pages
743 - 746
Database
ISI
SICI code
0040-4039(1996)37:6<743:OWAAAC>2.0.ZU;2-M
Abstract
An oligonucleotide containing alternating anionic and stereo-uniform c ationic dimethylaminopropylphosphoramidate linkages, d(T+T-)(7)T, is s hown to bind with unusually high affinity to DNA [poly(dA) and d(C(2)A (15)C(2))] and RNA [poly(rA)] targets in solutions of low ionic streng th. The isomeric oligomer with the opposite configuration at the phosp horamidate links binds much less efficiently.