ASYMMETRIC-SYNTHESIS .40. 2,3-DISUBSTITUTED PIPERIDINES VIA CHIRAL NON-RACEMIC LACTAMS

Authors
MICOUIN L QUIRION JC HUSSON HP
Citation
L. Micouin et al., ASYMMETRIC-SYNTHESIS .40. 2,3-DISUBSTITUTED PIPERIDINES VIA CHIRAL NON-RACEMIC LACTAMS, Tetrahedron letters, 37(6), 1996, pp. 849-852
Citations number
13
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
37
Issue
6
Year of publication
1996
Pages
849 - 852
Database
ISI
SICI code
0040-4039(1996)37:6<849:A.2PVC>2.0.ZU;2-X
Abstract
Optically pure 2,3-cis-disubstituted piperidines 7a and 7b have been p repared from chiral lactams 2. The first step involves C-2 functionali zation with Grignard reagent, then a diastereoselective reduction of r esulting oxazolidines 5 furnishes the desired piperidines 7.