LONG-LASTING IMMUNE-RESPONSE INDUCED BY RECOMBINANT BACILLUS-CALMETTE-GUERIN (BCG) SECRETION SYSTEM

Authors
WADA N OHARA N KAMEOKA M NISHINO Y MATSUMOTO S NISHIYAMA T NAITO M YUKITAKE H OKADA Y IKUTA K YAMADA T
Citation
N. Wada et al., LONG-LASTING IMMUNE-RESPONSE INDUCED BY RECOMBINANT BACILLUS-CALMETTE-GUERIN (BCG) SECRETION SYSTEM, Scandinavian journal of immunology, 43(2), 1996, pp. 202-209
Citations number
61
Categorie Soggetti
Immunology
Journal title
Scandinavian journal of immunology → ACNP
ISSN journal
03009475
Volume
43
Issue
2
Year of publication
1996
Pages
202 - 209
Database
ISI
SICI code
0300-9475(1996)43:2<202:LIIBRB>2.0.ZU;2-X
Abstract
The recombinant bacillus Calmette-Guerin (rBCG) secretion system utili zing an extracellular alpha antigen of Mycobacterium kansasii (alpha-K ) was characterized biochemically and immunologically. The human immun odeficiency virus type1 (HIV-1)p17(gag) B cell epitope fused to alpha- K was secreted in extremely large amounts. At least three mice out of seven inoculated with rBCG generated high titres of antibody to the ep itope. The long-lasting antibody production persisted more than 14 mon ths.