RECOMBINANT IMMUNOTOXINS

Authors
PASTAN I PAI LH BRINKMANN U FITZGERALD D
Citation
I. Pastan et al., RECOMBINANT IMMUNOTOXINS, Breast cancer research and treatment, 38(1), 1996, pp. 3-9
Citations number
25
Categorie Soggetti
Oncology
Journal title
Breast cancer research and treatment → ACNP
ISSN journal
01676806
Volume
38
Issue
1
Year of publication
1996
Pages
3 - 9
Database
ISI
SICI code
0167-6806(1996)38:1<3:RI>2.0.ZU;2-V
Abstract
Pseudomonas exotoxin has been genetically modified so that it targets cancer cells. This was accomplished by deleting its cell binding domai n and replacing it with Fv fragments of antibodies that react with bre ast, colon, and other cancers. Several recombinant immunotoxins are no w in clinical trials.