EOSINOPHILIA ASSOCIATED WITH PROLIFERATION OF CD3(-)8(-)ALPHA-BETA(+)T-CELLS WITH CHROMOSOME-16 ANOMALIES()4()

Authors
KITANO K ICHIKAWA N MAHBUB B UENO M ITO T SHIMODAIRA S KODAIRA H ISHIDA F KOBAYASHI H SAITO H OKUBO Y ENOKIHARA H KIYOSAWA K
Citation
K. Kitano et al., EOSINOPHILIA ASSOCIATED WITH PROLIFERATION OF CD3(-)8(-)ALPHA-BETA(+)T-CELLS WITH CHROMOSOME-16 ANOMALIES()4(), British Journal of Haematology, 92(2), 1996, pp. 315-317
Citations number
13
Categorie Soggetti
Hematology
Journal title
British Journal of Haematology → ACNP
ISSN journal
00071048
Volume
92
Issue
2
Year of publication
1996
Pages
315 - 317
Database
ISI
SICI code
0007-1048(1996)92:2<315:EAWPOC>2.0.ZU;2-9
Abstract
We describe a patient with eosinophilia and an abnormal CD3(+)4(-)8(-) alpha beta(+) T-cell population. Chromosomal analysis of sorted CD3(+) 4(-)8(-) cells revealed abnormal karyotypes on chromosome 16. In the p resence of IL-2 the production of IL-5 from CD3(+)4(-)8(-) cells was h igher than that from CD3(+)4(+)/8(+) cells. Eosinophil survival-enhanc ing activity in the patient serum was inhibited by a combination of an ti-IL-5 and anti-GM-CSF monoclonal antibodies. These data suggest that increased production of IL-5 and GM-CSF from the abnormal CD3(+)4(-)8 (-) cells might cause eosinophilia.