SUSTAINED COMPLETE CYTOLOGIC AND MOLECULAR REMISSION INDUCED BY DONORLEUKOCYTE INFUSIONS ALONE IN AN ACUTE MYELOBLASTIC-LEUKEMIA IN RELAPSE AFTER BONE-MARROW TRANSPLANTATION

Authors
BUZYNVEIL A BELANGER C AUDAT F HERMINE O BODEMER C RIBRAG V RADFORD I POIREL H CHANE C VALENSI F MACINTYRES E VARET B
Citation
A. Buzynveil et al., SUSTAINED COMPLETE CYTOLOGIC AND MOLECULAR REMISSION INDUCED BY DONORLEUKOCYTE INFUSIONS ALONE IN AN ACUTE MYELOBLASTIC-LEUKEMIA IN RELAPSE AFTER BONE-MARROW TRANSPLANTATION, British Journal of Haematology, 92(2), 1996, pp. 423-425
Citations number
10
Categorie Soggetti
Hematology
Journal title
British Journal of Haematology → ACNP
ISSN journal
00071048
Volume
92
Issue
2
Year of publication
1996
Pages
423 - 425
Database
ISI
SICI code
0007-1048(1996)92:2<423:SCCAMR>2.0.ZU;2-9
Abstract
Therapeutic options for treatment of recurrence of leukaemia after all ogeneic bone marrow transplantation (BMT) are limited. A beneficial ef fect of donor lymphocyte infusions (DLI) has not previously been descr ibed in acute myeloid leukaemia (AML) relapse. We report a case of AML with t(8;21), relapsing 3 months after BMT, who received DLI without adjuvant chemotherapy or growth factors. The patient developed acute G VHD and achieved a rapid complete remission of his AML by both cytolog ic and molecular criteria of at least 14 months duration, thereby show ing that DLI for AML in relapse after BMT is an alternative therapeuti c option.