Ta. Arkhipova et Ia. Avrutskaya, ELECTROCHEMICAL SYNTHESIS OF 2,4,5,6-TETRAAMINOPYRIMIDINE IN ACID-MEDIA, Russian journal of electrochemistry, 32(1), 1996, pp. 114-116
2,4,5,6-Tetraaminopyrimidine (AP), which is an intermediate product in
the synthesis of methotrexate intended for medical treatment of acute
leucosis, can be produced by electrochemical reduction of 2,4,6-tetra
amino-5-nitrosopyrimidine in alkaline and acid media. The advantage of
using the latter is the absence of sodium sulfate waste formed during
AP isolation from alkaline solutions. The conditions of the AP electr
osynthesis in sulfate medium are elaborated. The process is found to b
e catalyzed by Sn2+ ions.