M. Stolte et al., DIFFERENTIATION OF FOCAL FOVEOLAR HYPERPLASIA FROM HYPERPLASTIC POLYPS IN GASTRIC BIOPSY MATERIAL, Pathology research and practice, 191(12), 1995, pp. 1198-1202
Our objective was to investigate the question as to whether focal fove
olar hyperplasia and hyperplastic polyp can be differentiated in force
ps biopsy material from the stomach. Morphometric determination of the
height of the epithelium layer in forceps biopsy specimens was obtain
ed from 35 hyperplastic polyps, and forceps biopsy material was obtain
ed from 25 focal foveolar hyperplasias. The diagnosis of hyperplastic
polyp was confirmed by subsequent polypectomy. The medians and scatter
range of the epithelial layer height were calculated Using she t-test
for independent samples the question was examined as to whether there
is any statistically significant difference between hyperplastic poly
ps and focal foveolar hyperplasia in terms of the parameter ''height o
f the foveolar epithelial layer''. The measurements revealed that the
average height of foveolar epithelial cells in hyperplastic polyps is
37.70 mu m +/- 7.41 mu m. In the case of focal foveolar hyperplasia, t
he corresponding figure was only 24.26 mu m +/- 5.11 mu m. This differ
ence was statistically highly significant (p < 0.0001). In conclusion,
focal foveolar hyperplasia and hyperplastic polyp of the gastric muco
sa can readily be differentiated on the basis of architectural and cyt
ological criteria, even in forceps biopsy material. Since the hyperpla
stic polyp very probably does not evolve from focal foveolar hyperplas
ia, and the latter is not a pre-neoplastic condition or lesion, is is
proposed that focal foveolar hyperplasia should no longer be referred
to as ''gastric polyp,'' which would avoid unnecessary follow-up exami
nations and possibly even surgery.