USE OF IMMOBILIZED SYNTHETIC PEPTIDES FOR THE IDENTIFICATION OF CONTACT SITES BETWEEN HUMAN INTERLEUKIN-6 AND ITS RECEPTOR

Authors
WEIERGRABER O SCHNEIDERMERGENER J GROTZINGER J WOLLMER A KUSTER A EXNER M HEINRICH PC
Citation
O. Weiergraber et al., USE OF IMMOBILIZED SYNTHETIC PEPTIDES FOR THE IDENTIFICATION OF CONTACT SITES BETWEEN HUMAN INTERLEUKIN-6 AND ITS RECEPTOR, FEBS letters, 379(2), 1996, pp. 122-126
Citations number
28
Categorie Soggetti
Biophysics,Biology
Journal title
FEBS letters → ACNP
ISSN journal
00145793
Volume
379
Issue
2
Year of publication
1996
Pages
122 - 126
Database
ISI
SICI code
0014-5793(1996)379:2<122:UOISPF>2.0.ZU;2-N
Abstract
Synthetic peptides immobilized on cellulose membranes proved to be a p owerful tool for the identification of sites in the cytokine IL-6 invo lved in receptor binding. Similarly, a region in the extracellular par t of the IL-6 receptor which is important for interaction with its lig and was identified.