ANTITUMOR ,2-BIS(METHYLSULFONYL)-1-(2-CHLOROETHYL)HYDRAZINES

Several ,2-bis(methylsulfonyl)-1-(2-chloroethyl)hydrazines were synthe sized and primarily evaluated for antitumor activity against the murin e L1210 leukemia. All of the compounds tested were capable of producin g ''cures'' of mice bearing this tumor. One of the most active agents of this class, thyl)-2-[[(2-chlorothyl)-amino]carbonyl]hydrazine, was further evaluated against a spectrum of transplanted murine and human solid tumors. Pronounced activity was found against all of the tumors including the murine B16F10 melanoma, M109 lung carcinoma, M5076 retic ulum cell sarcoma, and the human LX-1 lung carcinoma. The activities o bserved compared favorably with those of the established antitumor dru gs, cyclophosphamide, mitomycin C, and the nitrosoureas, evaluated con comitantly.