EFFECT OF PRETREATMENT WITH KETOROLAC TROMETHAMINE ON POSTOPERATIVE PAIN FOLLOWING PERIODONTAL SURGERY

A double-blind, randomized, single-dose clinical trial to evaluate the analgesic efficacy of preoperative ketorolac tromethamine administrat ion on periodontal postoperative pain was designed. One group received 20 mg ketorolac immediately before periodontal flap surgery, and the other group received placebo. Naproxen sodium was allowed postoperativ ely as rescue medication. The visual analog scale was used to estimate pain. Postoperative pain was assessed hourly for the first 10 h on th e day of surgery and 4x daily on the 1st and 2nd postsurgical days. Ti ming and dose of rescue analgesic remedication were also recorded. Res ults indicated that preoperative treatment with ketorolac significantl y reduced initial pain intensity and delayed the onset of postoperativ e pain as compared to placebo. Incidence and amount of naproxen consum ption was similarly small in both ketorolac- and placebo-treated group s. No adverse reactions related to preoperative medication were observ ed.