EMERGENCE OF FLUOROQUINOLONE-RESISTANT ESCHERICHIA-COLI IN FECAL FLORA OF CANCER-PATIENTS RECEIVING NORFLOXACIN PROPHYLAXIS

Authors
CARRATALA J FERNANDEZSEVILLA A DOMINGUEZ FTMA GUDIOL F
Citation
J. Carratala et al., EMERGENCE OF FLUOROQUINOLONE-RESISTANT ESCHERICHIA-COLI IN FECAL FLORA OF CANCER-PATIENTS RECEIVING NORFLOXACIN PROPHYLAXIS, Antimicrobial agents and chemotherapy, 40(2), 1996, pp. 503-505
Citations number
28
Categorie Soggetti
Pharmacology & Pharmacy",Microbiology
Journal title
Antimicrobial agents and chemotherapy → ACNP
ISSN journal
00664804
Volume
40
Issue
2
Year of publication
1996
Pages
503 - 505
Database
ISI
SICI code
0066-4804(1996)40:2<503:EOFEIF>2.0.ZU;2-U
Abstract
We studied 122 stool samples collected from 25 patients with hematolog ic malignancies who received prophylactic norfloxacin. Fecal samples w ere obtained at admission and twice weekly thereafter during prophylax is. Fluoroquinolone-resistant Escherichia coli strains were isolated f rom the feces of 10 (40%) of the patients; two patients had fluoroquin olone-resistant E. coli strains prior to beginning norfloxacin treatme nt, and in the other eight patients, the strains appeared subsequently . One patient developed fluoroquinolone-resistant E. coli bacteremia a fter 10 days of norfloxacin administration.