A PROSPECTIVE POPULATION STUDY OF PSYCHOSOCIAL RISK-FACTORS FOR LATE-ONSET DEMENTIA

The role of psychosocial risk factors in the development of late onset , severe dementia was examined in a longitudinal prospective study of a representative sample followed from 70 to 79 years of age. Subjects with any signs of dementia at the age of 70 were excluded. Eighteen ri sk factors occurring before the age of 70 were studied, five from chil dhood and youth, five from adult age and eight from the age of 65-70. Thirty-eight subjects developed dementia, and they were compared to th e other 326 subjects. Death of a parent before the age of 16, previous arduous manual work, physical illness in the spouse after the age of 65 and serious illness in a child after the age of 65 made independent contributions to the prediction of dementia. There was a dose-respons e relationship: in subjects without exposure 3% developed dementia, in subjects with exposure to one or two risk factors 8% developed dement ia, and in subjects with exposure to three of more risk factors 20% de veloped dementia. The association with psychosocial risk factors was s imilar in the aetiological subgroups Alzheimer's disease and vascular dementia. There was no association with education or alcohol abuse. We suggest that the associations between psychosocial risk factors and d ementia are due to the effects of stress, but other interpretations ar e also possible. The results should be regarded as preliminary until c onfirmed by others.