TYRAMINE PRESSOR SENSITIVITY IN HEALTHY-SUBJECTS DURING COMBINED TREATMENT WITH MOCLOBEMIDE AND SELEGILINE

Objective: The objectives of this double-blind study were to assess th e tolerability and i.v. tyramine presser response during combined trea tment with moclobemide and selegiline. Subjects: Two parallel groups o f 12 healthy male and female subjects were treated with 200 mg moclobe mide or 5 mg selegiline b.d. for 14 days. On Day 7: selegiline or mocl obemide was added to the other treatment. IV tyramine presser tests we re conducted at baseline and at steady state during mono- and combined treatment. Results: Treatment with moclobemide and selegiline alone w as well tolerated, whereas combined treatment led to a slight increase in adverse events. Tyramine pressor sensitivity during moclobemide, s elegiline and moclobemide + selegiline treatment was enhanced, on aver age, by 2.4-, 1.3- and 8.4-times, respectively. Conclusions: Although combined treatment with moclobemide and selegiline was well tolerated, the supra-additive potentiation of the tyramine pressor effects means that dietary restriction of tyramine intake will be necessary during such combination therapy.