AUTOMATED SAMPLE PREPARATION BY ONLINE DIALYSIS AND TRACE ENRICHMENT - ANALYSIS OF MORPHINE, 6-MONOACETYLMORPHINE, CODEINE, ETHYLMORPHINE AND PHOLCODINE IN PLASMA AND WHOLE-BLOOD BY CAPILLARY GAS-CHROMATOGRAPHY AND CAPILLARY GAS-CHROMATOGRAPHY MASS-SPECTROMETRY

Authors
KROGH M CHRISTOPHERSEN AS RASMUSSEN KE
Citation
M. Krogh et al., AUTOMATED SAMPLE PREPARATION BY ONLINE DIALYSIS AND TRACE ENRICHMENT - ANALYSIS OF MORPHINE, 6-MONOACETYLMORPHINE, CODEINE, ETHYLMORPHINE AND PHOLCODINE IN PLASMA AND WHOLE-BLOOD BY CAPILLARY GAS-CHROMATOGRAPHY AND CAPILLARY GAS-CHROMATOGRAPHY MASS-SPECTROMETRY, Journal of chromatography. Biomedical applications, 621(1), 1993, pp. 41-48
Citations number
7
Categorie Soggetti
Chemistry Analytical
Journal title
Journal of chromatography. Biomedical applications → ACNP
ISSN journal
03784347
Volume
621
Issue
1
Year of publication
1993
Pages
41 - 48
Database
ISI
SICI code
0378-4347(1993)621:1<41:ASPBOD>2.0.ZU;2-K
Abstract
A fully automated sample preparation method for the determination of f ive opiates in human plasma and whole blood is described. The techniqu e combines dialysis and trace enrichment prior to gas chromatography a nd gas chromatography-mass spectrometry. Dialysis and trace enrichment on a polymer column was shown to be a highly reliable method for samp le preparation. The method can be used, after minor modification, to d etermine other basic drugs in plasma and whole blood. The method demon strates the potential of the automated sequential trace enrichment of dialysate (ASTED) system for automated sample preparation.