AUTOMATED SAMPLE PREPARATION BY ONLINE DIALYSIS AND TRACE ENRICHMENT - ANALYSIS OF MORPHINE, 6-MONOACETYLMORPHINE, CODEINE, ETHYLMORPHINE AND PHOLCODINE IN PLASMA AND WHOLE-BLOOD BY CAPILLARY GAS-CHROMATOGRAPHY AND CAPILLARY GAS-CHROMATOGRAPHY MASS-SPECTROMETRY
M. Krogh et al., AUTOMATED SAMPLE PREPARATION BY ONLINE DIALYSIS AND TRACE ENRICHMENT - ANALYSIS OF MORPHINE, 6-MONOACETYLMORPHINE, CODEINE, ETHYLMORPHINE AND PHOLCODINE IN PLASMA AND WHOLE-BLOOD BY CAPILLARY GAS-CHROMATOGRAPHY AND CAPILLARY GAS-CHROMATOGRAPHY MASS-SPECTROMETRY, Journal of chromatography. Biomedical applications, 621(1), 1993, pp. 41-48
A fully automated sample preparation method for the determination of f
ive opiates in human plasma and whole blood is described. The techniqu
e combines dialysis and trace enrichment prior to gas chromatography a
nd gas chromatography-mass spectrometry. Dialysis and trace enrichment
on a polymer column was shown to be a highly reliable method for samp
le preparation. The method can be used, after minor modification, to d
etermine other basic drugs in plasma and whole blood. The method demon
strates the potential of the automated sequential trace enrichment of
dialysate (ASTED) system for automated sample preparation.