F. Tanda et al., INTERCELLULAR-ADHESION MOLECULE-1 (ICAM-1) IMMUNOREACTIVITY IN WELL-DIFFERENTIATED THYROID PAPILLARY CARCINOMAS, Modern pathology, 9(1), 1996, pp. 53-56
Fifty-nine cases of tumors, 51 taken from the thyroid gland including
17 well-differentiated papillary, 1 medullary and 3 follicular carcino
mas, 14 follicular adenomas, 16 nodular goiters and 8 cases selected f
rom other sites; 5 breast carcinomas; 1 melanoma; 1 Merkel cell tumor;
and 1 squamous cell carcinoma of the uterine cervix, were investigate
d for intercellular adhesion molecule-1 (ICAM-1) expression. All cases
of well-differentiated papillary thyroid carcinoma showed positivity
for ICAM-1, whereas the follicular carcinomas, follicular adenomas, an
d all but one nodular goiters were negative. It is suggested that the
occurrence of ICAM-1 on the thyroid cell surfaces in well-differentiat
ed papillary thyroid carcinomas may contribute to the understanding of
their biology and could be of potential significance for diagnostic p
urposes.