DETERMINATION OF ETOPOSIDE IN BLOOD BY LIQUID-CHROMATOGRAPHY WITH ELECTROCHEMICAL DETECTION

Authors
EISENBERG EJ EICKHOFF WM
Citation
Ej. Eisenberg et Wm. Eickhoff, DETERMINATION OF ETOPOSIDE IN BLOOD BY LIQUID-CHROMATOGRAPHY WITH ELECTROCHEMICAL DETECTION, Journal of chromatography. Biomedical applications, 621(1), 1993, pp. 110-114
Citations number
17
Categorie Soggetti
Chemistry Analytical
Journal title
Journal of chromatography. Biomedical applications → ACNP
ISSN journal
03784347
Volume
621
Issue
1
Year of publication
1993
Pages
110 - 114
Database
ISI
SICI code
0378-4347(1993)621:1<110:DOEIBB>2.0.ZU;2-#
Abstract
A liquid chromatographic (LC) method for determination of etoposide in dog blood is described. The technique includes solvent extraction of etoposide using a dichloroethane-hexane mixture and reconstitution of the drug in an aqueous reconstitution solution. The samples are analyz ed by reversed-phase LC with electrochemical detection. Validation of the method demonstrated good sensitivity, precision and reproducibilit y. The method is useful for the study of etoposide pharmacokinetics in the dog.