Purpose: To their knowledge, the authors report the first recognized c
ase of ductal adenocarcinoma of the lacrimal gland (histologic equival
ent of salivary duct carcinoma). Primary adenocarcinoma of the lacrima
l gland is rare and has been described generically. In contrast, prima
ry adenocarcinomas of the major and minor salivary glands are much mor
e common and have been classified into histopathologic subtypes that h
ave different clinical characteristics and outcomes. Methods: A 68-yea
r-old man presented with a 6-month history of a painless mass in the r
ight upper outer eyelid. The authors describe the clinical, radiologic
, and histopathologic features of this case and review the lacrimal gl
and literature. Results: A modified en bloc orbitectomy was performed,
and postoperative radiotherapy was administered. The patient was aliv
e and well without evidence of tumor recurrence 10 months after surger
y. Conclusion: The World Health Organization classification of salivar
y adenocarcinomas (1991) provides a framework for further insight into
the presentation and biologic behavior of the less common lacrimal ca
rcinomas.