EVALUATION OF MULTIPEPTIDE-COPPER COMPLEX MEDICATIONS ON OPEN WOUND-HEALING IN DOGS

Twenty adult laboratory beagles were participants in a 21-day study ev aluating the effects of a tripeptide- and tetrapeptide-copper complex on open wound healing of dogs as compared to vehicle/placebo-treated a nd untreated control wounds. Initially, the wounds treated with either of the multipeptide-copper complex medications produced a greater tha n normal amount of exudative material, however, they developed granula tion tissue sooner than the control or vehicle/placebo-treated wounds. The wounds also had a significantly greater percentage of contraction and total wound healing at seven days compared to vehicle/placebo-tre ated and control wounds. The granulation tissue formed after treatment with both multipeptide-copper complexes tended to be exuberant, which in some cases appeared to interfere with epithelialization of the wou nds at 21 days.