SEPARATION AND STRUCTURAL ELUCIDATION OF THE HYDROLYSIS COMPOUNDS OF LOPRAZOLAM

The hydrolysis of loprazolam in acidic and basic aqueous media was stu died using spectroscopic and chromatographic techniques (UV, HPLC, H-1 NMR and GC-MS). 2-Amine-5-nitro-2'-chlorobenzophenone was found as th e major hydrolysis derivative in basic media, whereas in acidic media there are two major derivatives, clonazepam and the open compound obta ined by scission of the 4,5-azomethine bond of loprazolam.