STUDY ON IN-VITRO STABILITY OF POLYMERIZED LIPOSOMES

We studied the stability of liposomes composed of polymerized phosphol ipid, (octadeca-2,4-dienoyl)-sn-glycero-3-phosphocholine (DENPC), to p H changes and the presence of bile salts, monitoring the leakage of H- 3-sucrose entrapped in liposomes. The stability of polymerized DENPC-l iposomes to acidic media (pH 3.3 and 2), and the presence of bile salt s (20 mM), was much higher than that of nonpolymerized DENPC-liposomes and liposomes composed of conventional phospholipids. The stability o f polymerized DENPC-liposomes was increased in the presence of carboxy methyl chitin (CM-chitin).