INTERACTION OF THE PYRIDOINDOLE STOBADINE WITH ALKOXYL AND STABLE FREE-RADICALS

Stobadine, a pyridoindole derivative which has been synthesized in sea rch of new antiarrhytmic drugs, was able to interact with alpha-diphen yl-beta-picrylhydrazyl (DPPH.) a stable free radical, Its scavenging p otential was in the same order of magnitude as that of web known stron g antioxidants, The scavenging effect of antioxidants tested increased in the order: stobadine, ascorbic acid, trolox, cysteine, Stobadine e xerted a scavenging effect also towards alkoxyl radicals in a nonpolar solvent in the canthaxantin bleaching test, In this test stobadine wa s more effective than trolox.