INDUCTION OF PGH SYNTHASE AND C-FOS MESSENGER-RNA DURING EARLY REPERFUSION OF ISCHEMIC RAT-BRAIN

Authors
HOLTZ ML KINDY MS CRADDOCK S MOORE RW PETTIGREW LC
Citation
Ml. Holtz et al., INDUCTION OF PGH SYNTHASE AND C-FOS MESSENGER-RNA DURING EARLY REPERFUSION OF ISCHEMIC RAT-BRAIN, Molecular brain research, 35(1-2), 1996, pp. 339-343
Citations number
26
Categorie Soggetti
Neurosciences
Journal title
Molecular brain research → ACNP
ISSN journal
0169328X
Volume
35
Issue
1-2
Year of publication
1996
Pages
339 - 343
Database
ISI
SICI code
0169-328X(1996)35:1-2<339:IOPSAC>2.0.ZU;2-X
Abstract
We examined the effect of reversible ischemia on the transcription of prostaglandin endoperoxide synthase (PGHS-1) and c-fos mRNA in rat cer ebral cortex. The level of PGHS-1 mRNA climaxed after 30 min of ischem ia whereas transcription of c-fos mRNA peaked after 60 min of postisch emic reperfusion. We conclude that cerebral ischemia causes early tran scription of PGHS-1, without modulation by the c-fos gene or its trans lated product.