Ml. Holtz et al., INDUCTION OF PGH SYNTHASE AND C-FOS MESSENGER-RNA DURING EARLY REPERFUSION OF ISCHEMIC RAT-BRAIN, Molecular brain research, 35(1-2), 1996, pp. 339-343
We examined the effect of reversible ischemia on the transcription of
prostaglandin endoperoxide synthase (PGHS-1) and c-fos mRNA in rat cer
ebral cortex. The level of PGHS-1 mRNA climaxed after 30 min of ischem
ia whereas transcription of c-fos mRNA peaked after 60 min of postisch
emic reperfusion. We conclude that cerebral ischemia causes early tran
scription of PGHS-1, without modulation by the c-fos gene or its trans
lated product.