Acute idiopathic pancreatitis is a term used when no underlying cause
has been identified on routine investigation. However, more specialise
d investigations may identify aetiological factors, biliary sludge and
sphincter of Oddi dysfunction for example, in 38-72% of patients with
recurrent episodes. Treatment of these abnormalities may prevent furt
her episodes of pancreatitis. The aim of this study was to follow up a
nd determine the outcome in patients with a first episode of idiopathi
c pancreatitis, and thus determine the need for further investigation
and treatment in this group of patients. Thirty one patients with a si
ngle episode of idiopathic pancreatitis were studied who had no specia
lised investigations or specific treatment. During a median follow up
of 36 months only one patient has had recurrent pancreatitis. Two pati
ents experienced a single episode of unexplained abdominal pain; serum
amylase, liver biochemistry, and abdominal ultrasound were all normal
and the pain resolved within 48 hours. In conclusion, in the medium t
erm, the prognosis is good after a first episode of idiopathic pancrea
titis and specialised investigation is unnecessary.