SYNTHESES AND EXPLORATION OF NEW BIOLOGICAL-ACTIVITIES IN ETHYL 6 7-SUBSTITUTED AND 6,7-DISUBSTITUTED QUINOLIN-4-ONE-3-CARBOXYLATES/

Syntheses of a number of ethyl 1H, 4H-quinolin-4-one-3-carboxylates ca rrying substituted piperidinedione ring at position 6 (25 & 31-35), te trahydrofuranone (37) or tetraydropyridazinone ring (39) at position 7 and hydroxy and hydroxymethyl substituents at positions 6 and 7 respe ctively (41) of the quinolone ring, are reported here, of these compou nds on the in vitro heme polymerase activity of Plasmodia and on the i n vitro fungal growth are described.