3-SUBSTITUTED ALANINES INACTIVATE GAMMA-AMINOBUTYRIC-ACID AMINOTRANSFERASE BY THE SAME MECHANISM AS DO 4-AMINO-5-HALOPENTANOIC ACID ANALOGS

Authors
SILVERMAN RB OLSON GT
Citation
Rb. Silverman et Gt. Olson, 3-SUBSTITUTED ALANINES INACTIVATE GAMMA-AMINOBUTYRIC-ACID AMINOTRANSFERASE BY THE SAME MECHANISM AS DO 4-AMINO-5-HALOPENTANOIC ACID ANALOGS, Bioorganic & medicinal chemistry letters, 6(2), 1996, pp. 143-146
Citations number
11
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
6
Issue
2
Year of publication
1996
Pages
143 - 146
Database
ISI
SICI code
0960-894X(1996)6:2<143:3AIGA>2.0.ZU;2-U
Abstract
L-Serine O-sulfate inactivates gamma-aminobutyric acid aminotransferas e (GABA-AT) by a mechanism that involves elimination of the leaving gr oup and an enamine rearrangement, the same mechanism as that for the i nactivation of GABA-AT by 4-amino-5-fluoropentanoic acid.