SYNTHESIS, ENZYMATIC PHOSPHORYLATION AND ANTIVIRAL ACTIVITY OF ACYCLIC DIENYL PHOSPHONATE DERIVATIVES OF GUANINE

Authors
NAVE JF CASARA PJ TAYLOR DL TYMS AS KENNY M HALAZY S
Citation
Jf. Nave et al., SYNTHESIS, ENZYMATIC PHOSPHORYLATION AND ANTIVIRAL ACTIVITY OF ACYCLIC DIENYL PHOSPHONATE DERIVATIVES OF GUANINE, Bioorganic & medicinal chemistry letters, 6(2), 1996, pp. 179-184
Citations number
20
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
6
Issue
2
Year of publication
1996
Pages
179 - 184
Database
ISI
SICI code
0960-894X(1996)6:2<179:SEPAAA>2.0.ZU;2-N
Abstract
The synthesis, phosphorylation by guanylate kinase, anti HIV-1 and ant i-herpesvirus activity of two acyclic dienyl phosphonate derivatives o f guanine are described. (E)-9-(5-phosphono-3-methylene-4-pentenyl)gua nine (4) was identified as an excellent substrate of guanylate kinase and a significant inhibitor of HIV-1 replication.