SUCCESSFUL TREATMENT OF SECONDARY HYPERPARATHYROIDISM IN HEMODIALYSIS-PATIENTS WITH ORAL PULSE 1-ALPHA-HYDROXY-CHOLECALCIFEROL THERAPY

We have used high-dose oral pulse therapy with 1 alpha-hydroxycholecal ciferol (1 alpha-OH-D-3) to treat 40 hemodialysis patients suffering f rom secondary hyperparathyroidism. Forty patients with intact parathyr oid hormone (PTH) levels of > 150 pg/ml were treated with 4 mu g oral 1 alpha-OH-D-3 twice weekly for 1 year. The mean PTH level was 515 +/- 50 pg/ml prior to treatment, which fell to 191 +/- 42 pg/ml after 6 m onths of treatment (p < 0.00001), and to 164 +/- 39 pg/ml after 12 mon ths of treatment. Patients with very high PTH levels (> 800 pg/ml) sup pressed less well than patients with lower levels (150-300 pg/ml). The therapeutic end point of PTH < 100 pg/ml was achieved in 23 patients (58%). The main side effect of the treatment was hypercalcemia, but th is was symptomatic in only 3 patients, all above the age of 70 years. In summary, oral high-dose pulse therapy with 1 alpha-OH-D-3 was highl y effective in suppressing PTH levels in hyperparathyroid hemodialysis patients, and side effects were relatively few.