ESTIMATION OF STATISTICAL MOMENTS FOR DESFERRIOXAMINE AND ITS IRON AND ALUMINUM CHELATES - CONTRIBUTION TO OPTIMIZATION OF THERAPY IN UREMIC PATIENTS

We investigated the best time of administration of desferrioxamine (DF O) with respect to the dialysis session, using the approach of the sto chastic dynamic system, integrated with the classical pharmacokinetic models. In the 6 patients studied, the mean arrival times of DFO, alum inoxamine (A10) and ferrioxamine (FO) were, respectively, 193, 1,350 a nd 126 min, the mean residence times were 1,048, infinite, 1,190 min, respectively. A10 serum levels reach steady state in a mean time of 7 h and 22 min and remain stable in the interdialytic period. FO achieve s a peak at the end of DFO infusion and declines during the interdialy tic period. DFO, A10 and FO persist a very long time in the body of th e uremic patient, thus the dialysis session should be administered whe n A10 and FO reach steady state. With a dose of 5-10 mg/kg b.w. of DFO , we propose to start the dialysis 8-12 h after the infusion if the ma in purpose is to treat Al overload or 2-3 h after the infusion if the main purpose is the treatment of hemosiderosis.