INVESTIGATIONS IN THE HUMORAL IMMUNE-RESP ONSE IN PUPPIES AFTER FIRSTIMMUNIZATION WITH DIFFERENT COMBINATION VACCINES .2. COMPONENT AGAINST PARVOVIROSIS

Serological examinations were performed in 62 puppies for the evaluati on of 5 combined vaccines regarding the induction of a humoral immune response against parvovirus. The first vaccination was performed at th e age of 9-10 weeks, the second vaccination at 13-14 weeks. Serologica l examinations for antibodies against the CPV were performed at the ti me of the first vaccination, the second vaccination and 4 weeks after the second vaccination. Puppies which showed praevaccinal antibodies a gainst CPV and did not seroconvert after vaccination were not included into the final computation. Out of the 13 puppies vaccinated with End uracell 7(R), none showed praevaccinal humoral antibodies. At the fina l examination, 7 animals (63.6%) showed CPV antibodies. Of 13 puppies vaccinated with Vetamun(R), none showed praevaccinal antibodies. At th e final examination 4 animals (30.8%) had seroconverted. Of 13 puppies vaccinated with Dohyvac Galaxy + L(R), one had praevaccinal humoral a ntibodies. Al the final examination 41.7% of the animals showed antibo dies against CPV. 12 puppies vaccinated with Canlan DPAL(R) did not sh ow praevaccinal antibodies. At the time of the last examination 50% of the animals had seroconverted. II dogs were vaccinated at the age of 6 weeks with Enduracell CPV(R), 4 weeks later 6 animals showed antibod ies. At the final evaluation 10 of 11 vaccinated puppies had positive titers. Possible causes for the limited humoral immune response and in teractions with other components are discussed.