PREPARATION OF 2,4-DIHYDROXYBENZALDEHYDE BY THE VILSMEIER-HAACK REACTION

Authors
MENDELSON WL HAYDEN S
Citation
Wl. Mendelson et S. Hayden, PREPARATION OF 2,4-DIHYDROXYBENZALDEHYDE BY THE VILSMEIER-HAACK REACTION, Synthetic communications, 26(3), 1996, pp. 603-610
Citations number
10
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Synthetic communications → ACNP
ISSN journal
00397911
Volume
26
Issue
3
Year of publication
1996
Pages
603 - 610
Database
ISI
SICI code
0039-7911(1996)26:3<603:PO2BTV>2.0.ZU;2-1
Abstract
An efficient synthesis of 2,4-dihydroxybenzaldehyde (1) from resorcino l via the Vilsmeier-Haack reaction has been developed. Either phosphor ous oxychloride/DMF or oxalyl chloride/DMF produces 1 in yields of 65- 75%. The intermediate formamidinium salts have been characterized.