LIPID PROFILES AND BLOOD-PRESSURE - ARE THEY RISK-FACTORS FOR THE DEVELOPMENT OF EARLY BACKGROUND RETINOPATHY AND INCIPIENT NEPHROPATHY IN CHILDREN WITH INSULIN-DEPENDENT DIABETES-MELLITUS
O. Kordonouri et al., LIPID PROFILES AND BLOOD-PRESSURE - ARE THEY RISK-FACTORS FOR THE DEVELOPMENT OF EARLY BACKGROUND RETINOPATHY AND INCIPIENT NEPHROPATHY IN CHILDREN WITH INSULIN-DEPENDENT DIABETES-MELLITUS, Acta paediatrica, 85(1), 1996, pp. 43-48
The objective of this study is to examine the influence of lipid profi
les and blood pressure on the development of microvascular complicatio
ns in adolescents with insulin-dependent diabetes mellitus (IDDM) in a
matched pairs study. Patients with early background retinopathy (n=21
) or microalbuminuria (n=15) and their respective statistical twins pa
rticipated in the study. Serum total cholesterol, high-density lipopro
tein (HDL) cholesterol, fasting triglycerides, glycosylated haemoglobi
n A(1c) (Hb A(1c)), and systolic and diastolic blood pressure during 3
years prior to the development of early background retinopathy or inc
ipient nephropathy were examined. The multivariate discriminant analys
is demonstrated glycaemic control and HDL cholesterol to be the most i
mportant variables related to the development of retinal lesions (84%
correctness), and diastolic blood pressure to be associated with micro
albuminuria (57% correctness). In addition to poor glycaemic control,
different factors seem to be important for the early retinal or renal
lesions of juvenile IDDM.