Om. Grindel et al., DISORDERS OF HIGHER CORTICAL FUNCTIONS IN HYPOTHALAMIC-LESIONS AND THEIR REFLECTION IN EEG - COMPUTER-ANALYSIS, Zurnal vyssej nervnoj deatelnosti im. I.P. Pavlova, 45(6), 1995, pp. 1101-1111
In order to reveal correlations between disturbances in higher cortica
l functions and characteristics of electrical activity 70 patients wit
h pathological foci in the hypothalamic regions were examined using co
mputer data processing. Destruction of the normal intercentral relatio
ns between EEG rhythms develops under the influence of the hypothalami
c focus, The process builds up with the aggravation of cortical disord
ers (mnestic, emotional-affective, consciousness oppression with sleep
inversion). General decrease of EEG coherence is observed with the hi
ghest destruction of correlations in the frontal cortical areas, The s
tructure of high-frequency alpha-rhythm becomes deranged even in sligh
t cortical disorders, its coherence decreases predominantly in the fro
ntal cortical areas, With intensification of the pathological process
in the focus, the stage of delta-rhythm coherence increase is observed
and at the background of general destruction of correlations new, pat
hological intercentral relations develop. Using a BRAINLOC computer te
chnique <<sources>> of the delta- and theta-activity have been localiz
ed in the medio-basal brain regions, The area of localization is speci
fic for hypothalamic lesions, The <<source>> is mostly expressed in th
e slightest pathology of higher cortical functions, With aggravation o
f the process in the hypothalamic pathological focus and further deran
gement in the cortical functions expression of the <<sources>> reduces
up to their complete disintegration in coma.