N. Balasubramaniyan et al., ROLE OF SERUM ENZYMES IN ASSESSING THE EFFICACY OF RADIATION-THERAPY FOR HUMAN CARCINOMA OF UTERINE CERVIX, Journal of clinical biochemistry and nutrition, 19(2), 1995, pp. 97-105
In different stages of carcinoma of the uterine cervix, the activities
of serum 5'-nucleotidase, lactate dehydrogenase (LDH), phosphohexose
isomerase (PI-II), gamma-glutamyl transpeptidase (GGT), transaminases,
and phosphatases were studied before and after radiation treatment. G
lycolytic enzymes (LDH, PI-II) were found to be increased from stage I
onwards, whereas GGT, glutamate oxaloacetate transaminase, glutamate
pyruvate transaminase, and acid and alkaline phosphatases increased on
ly in the advanced stages (stages III, IV), when compared with normal
values. 5'-Nucleotidase was found to be increased significantly from s
tage II onwards when compared with the normal. The increased levels of
these enzymes were reversed to near normal levels after radiotherapy.
The increased levels of serum transaminases, phosphatases, and GGT in
the advanced stages of carcinoma of uterine cervix may be explained o
n the basis of liver involvement and bone metastasis. The degree of in
crease in the activities of PI-II and LDH may reflect the status of th
e cancer. The activity of 5'-nucleotidase in serum may be used as an a
dditional marker to assess the status of carcinoma of uterine cervix u
nder circumstances when other markers fail to provide clear indication
s.