Js. Murray et al., PARTITION-COEFFICIENTS OF NITROAROMATICS EXPRESSED IN TERMS OF THEIR MOLECULAR-SURFACE AREAS AND ELECTROSTATIC POTENTIALS, Journal of physical chemistry, 97(51), 1993, pp. 13807-13809
We have applied our general interaction properties function (GIPF) to
the correlation analysis of octanol/water and acetonitrile/NaCl-satura
ted-water partition coefficients, P-ow and P-aw for benzene, toluene,
and nine of their nitro derivatives. The GIPF approach expresses physi
cal properties in terms of molecular surface area in conjunction with
several statistically-based quantities related to the surface electros
tatic potential; all of these have been evaluated through ab initio SC
F-MO calculations. Very good dual- and three-parameter relationships a
re obtained for both log P-ow and log P-aw. We find that the positive
potentials above and below the nitroaromatic rings are important deter
minants of P-ow whereas the regions of negative potential are not high
ly significant for either P-ow or P-aw.