SONIC HEDGEHOG - MAKING THE GRADIENT

Authors
BUMCROT DA MCMAHON AP
Citation
Da. Bumcrot et Ap. Mcmahon, SONIC HEDGEHOG - MAKING THE GRADIENT, Chemistry & biology, 3(1), 1996, pp. 13-16
Citations number
23
Categorie Soggetti
Biology
Journal title
Chemistry & biology → ACNP
ISSN journal
10745521
Volume
3
Issue
1
Year of publication
1996
Pages
13 - 16
Database
ISI
SICI code
1074-5521(1996)3:1<13:SH-MTG>2.0.ZU;2-G
Abstract
The amino-terminal peptide of Sonic hedgehog is a cell-tethered molecu le, which nevertheless seems to provide a developmental signal that ac ts at a distance and has different effects depending on its concentrat ion. Recent structural data suggest that zinc-dependent proteolysis ma y somehow be involved in Sonic hedgehog's function.