MODELIZATION OF COORDINATED CHANGES OF ADENYLATE ENERGY-CHARGE AND ATP ADP RATIO - APPLICATION TO ENERGY-METABOLISM IN INVERTEBRATE AND VERTEBRATE SKELETAL-MUSCLE/

Regulation of the coordinated adenylate energy charge (AEC) and ATP/AD P ratio variations was studied with the did of computer-made simulatio ns. When the equilibrium state for the adenylate kinase-catalyzed reac tion has been assumed the function describing the coordinated REC and ATP/ADP ratio variations can be simply derived from the formulas descr ibing these 2 parameters. The model was used to analyze incidence of A MP deamination in the coordinated regulation of cellular energy metabo lism.