ROLE OF IRON IN PATHOGENESIS OF GUINEA-PIGS INFECTED WITH YERSINIA-ENTEROCOLITICA O-3

Examined have been the pathogenesis of guinea pigs preliminarily overl oad with iron, an infected with Yersinia enterocolitica 0:3 in a logar ithmic and stationary phase of development, cultivated at 25-degrees-C and 37-degrees-C. Dextrofer-100 (Fedex-100) medicine have been used a s an iron source. The results show that in spite of the phase of devel opment and cultivation temperature, the iron excess does not increase the bacterial virulence of the strain used so far. The morphological c hanges in the mesenterial lymphatic nodes, small intestines, spleen an d liver of guinea pigs treated with iron, and then, infected with Y. e nterocolitica, are more slightly expressed as compared with animals in fected with Y. enterocolitica only. The investigations suggested so fa r, have attested that Yersinia enterocolitica 0:3 does not contain a g ene responsible for the synthesis of the protein participating in iron uptake.