ATTEMPTS AT CREATING A VACCINE AGAINST EB OLA FEVER

Data on the immunopathogenesis of Ebolo fever in laboratory animals ar e presented and the efficacy of some methods of vaccine prophylaxis di scussed. Antiviral immunity induced in guinea pigs by injection of ina ctivated viral agents did not protect them from infection, whereas inj ections of a nonlethal strain of the virus in ascending doses led to t he formation of immunity preventing the development of disease upon in oculation with a lethal strain in high doses. The role of some viral p eptides in the development of immune response is shown and variants of recombinant constructions for the prevention of Ebola fever are offer ed.