Lg. Karpovich et al., COMPARATIVE-STUDY OF THE IMMUNOGENICITY O F INACTIVATED VACCINE HEP-A-IN-VAC AGAINST HEPATITIS-A AS SHOWN BY EXPERIMENTAL AND CLINICAL-STUDIES, Voprosy virusologii, 40(6), 1995, pp. 268-270
Comparative analysis of the specific activities of various batches of
Hep-A-in-Vac vaccine showed that the immunologic efficacy of the agent
directly depended on the content of hepatitis A virus antigen in the
vaccine dose. The results of studying the immunogenicity of the agent
on volunteers are compatible with the results of experimental studies
and indicate that the test of guinea pigs adequately assesses this cha
racteristic. Assessment of the immunogenic properties of Hep-A-in-Vac
prepared using improved technology indicates that Russian vaccine inje
cted three times in a dose containing at least 40 U EIA ensures 87.5%
seroconversion in adult seronegative volunteers with the mean geometri
cal titer of antibodies to hepatitis A virus equal to 683 mIU/ml.