Vd. Poryvayev, THERMODYNAMIC ANALYSIS OF OXIDATIVE INACT IVATION OF INFLUENZA-VIRUS AND LIPID-PEROXIDATION IN VIRUS ENVELOPES, Voprosy virusologii, 40(6), 1995, pp. 273-276
The ''activation energy'' values for virus inactivation (22.2 kcal/ mo
l) calculated using Arrenius formula and the levels of accumulation of
the final product of lipid peroxidation, fluorescent pigment (21.2 kc
al/mol), in virus envelopes were found to be iu good correlation for p
urified influenza A/PR8/34 virus suspensions stored at temperatures fr
om 6 to 37 degrees C. A ''lipid'' mechanism of inactivation of envelop
ed viruses is proposed, permitting, together with the ''nucleic'' and
''protein'' mechanisms, a satisfactory interpretation of the relations
hip between tile stability of viral material and the medium compositio
n, lipid composition of virus envelopes, and other meters.