EXPRESSION OF THE MACROPHAGE SCAVENGER RECEPTOR, A MULTIFUNCTIONAL LIPOPROTEIN RECEPTOR, IN MICROGLIA ASSOCIATED WITH SENILE PLAQUES IN ALZHEIMERS-DISEASE
Rh. Christie et al., EXPRESSION OF THE MACROPHAGE SCAVENGER RECEPTOR, A MULTIFUNCTIONAL LIPOPROTEIN RECEPTOR, IN MICROGLIA ASSOCIATED WITH SENILE PLAQUES IN ALZHEIMERS-DISEASE, The American journal of pathology, 148(2), 1996, pp. 399-403
The macrophage scavenger receptor is a multi-functional receptor whose
ligands include oxidized low density lipoprotein (LDL), as well as se
veral other polyanionic macromolecules. Although the capacity of the r
eceptor to bind modified LDL has implicated in the process of atherosc
lerosis, its physiological role remains uncertain. We have examined hu
man brain for expression of macrophage scavenger receptor as part of o
ngoing studies of lipoprotein receptors in the central nervous system.
The receptor is expressed on microglia, but not on astrocytes, neuron
s, or vessel-associated structures. In Alzheimer disease, there is str
ong expression of the scavenger receptor in association with senile pl
aques.