SEPARATION OF DRUG ENANTIOMERS BY CAPILLARY ELECTROPHORESIS ALPHA-CYCLODEXTRIN AS CHIRAL SOLVATING AGENT

Authors
LIN BC JI YB CHEN YY EPPERLEIN U KOPPENHOEFER B
Citation
Bc. Lin et al., SEPARATION OF DRUG ENANTIOMERS BY CAPILLARY ELECTROPHORESIS ALPHA-CYCLODEXTRIN AS CHIRAL SOLVATING AGENT, Chromatographia, 42(1-2), 1996, pp. 106-110
Citations number
24
Categorie Soggetti
Chemistry Analytical","Biochemical Research Methods
Journal title
Chromatographia → ACNP
ISSN journal
00095893
Volume
42
Issue
1-2
Year of publication
1996
Pages
106 - 110
Database
ISI
SICI code
0009-5893(1996)42:1-2<106:SODEBC>2.0.ZU;2-3
Abstract
Enantiomer separation by capillary zone electrophoresis was studied fo r a set of 59 chiral drugs. With alpha-cyclodextrin as chiral solvatin g agent, six enantiomeric pairs could be resolved. Baseline separation was achieved for clidinium bromide, oxomemazine and tetryzoline, wher eas ketamine, orphenadrine, tropicamide and others require further opt imization. Aliphatic and monocyclic compounds prevail among compounds recognized by alpha-cyclodextrin, Statistical analysis reveals that a medium degree of migration retardation offers the best chance for succ essful separation.