CARACASANDIAMIDE, A TRUXINIC HYPOTENSIVE AGENT FROM VERBESIN-CARACASANA

Authors
DELLEMONACHE G BOTTA B DELLEMONACHE F ESPINAL R DEBONNEVAUX SC DELUCA C BOTTO M CORELLI F DEI D GACSBAITZ E CARMIGNANI M
Citation
G. Dellemonache et al., CARACASANDIAMIDE, A TRUXINIC HYPOTENSIVE AGENT FROM VERBESIN-CARACASANA, Bioorganic & medicinal chemistry letters, 6(3), 1996, pp. 233-238
Citations number
10
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
6
Issue
3
Year of publication
1996
Pages
233 - 238
Database
ISI
SICI code
0960-894X(1996)6:3<233:CATHAF>2.0.ZU;2-R
Abstract
A second hypotensive agent from Verbesina caracasana is shown to be th e truxinic type dimer of the previously isolated 3,4-dimethoxycinnamoy l guanidinoamide. The new compound gave by alkaline hydrolysis a cryst alline monoamide, which in turn by acid hydrolysis gave 3',4'-dimethox y-beta-truxinic acid, identical with a synthetic specimen.