SYNTHESIS AND BIOLOGICAL-ACTIVITY OF THE NEURONAL CALCIUM-CHANNEL BLOCKER 2-AMINO-1-(2,5-DIMETHOXYPHENYL)-5-TRIFLUOROMETHYL BENZIMIDAZOLE (NS-649)

Authors
VARMING T CHRISTOPHERSEN P MOLLER A PETERS D AXELSSON O NIELSEN EO
Citation
T. Varming et al., SYNTHESIS AND BIOLOGICAL-ACTIVITY OF THE NEURONAL CALCIUM-CHANNEL BLOCKER 2-AMINO-1-(2,5-DIMETHOXYPHENYL)-5-TRIFLUOROMETHYL BENZIMIDAZOLE (NS-649), Bioorganic & medicinal chemistry letters, 6(3), 1996, pp. 245-248
Citations number
18
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
6
Issue
3
Year of publication
1996
Pages
245 - 248
Database
ISI
SICI code
0960-894X(1996)6:3<245:SABOTN>2.0.ZU;2-Y
Abstract
The substituted benzimidazole, NS-649, has been shown to be a blocker of neuronal calcium channels in patch-clamp studies. NS-649 dose-depen dently inhibited release of D-aspartate from cerebellar granule neuron s. The neuroprotective effect of this compound in in vitro and in vivo models of ischemia was demonstrated.